In 2010, Simmons said he regretted voting for Barack Obama and criticized the 2009 health care reforms. Following Obama's 2011 speech on the Middle East in which the President called on Israel and the Palestinians to negotiate a settlement "based on the 1967 lines with mutually agreed swaps", Simmons told CNBC that Obama was gravely misguided. "If you have never been to the moon, you can't issue policy about the moon. For the president to be sitting in Washington D.C. and saying, 'Go back to your '67 borders in Israel' – how about you live there and try to defend an indefensible border – nine miles (14 km) wide?" Simmons also accused the United Nations of being "the most pathetic body on the face of the earth".
Simmons has boasted many times about having bedded thousands of women. In 2010, he claimed the tally stood at 5,000 and that he has a Polaroid picture of each liaison, including the hotel key where it took place. A number of years prior, as a guest on TSN's Off The Record with Michael Landsberg, Simmons told fellow guest Thea Andrews he had slept with 4,500 women, to which Andrews replied she was not interested in being 4,501. The show's other guest, Mark Tewksbury, offered himself to Simmons instead, to which Simmons declined. Tewksbury would state in a 2012 interview with the National Post that Simmons shook his head at Tewksbury off-camera.
Gene Simmons' Kiss character, The Demon, is a playable character in Kiss: Psycho Circus: The Nightmare Child. Simmons also has a large role in the 2010 music video game Guitar Hero: Warriors of Rock. In addition to narrating the main storyline, voicing the character Demigod of Rock in cutscenes, and doing advertising for the game, the Kiss song "Love Gun" is playable.