Upon his return to Tunis, after his exhausting trip across the Sahara to open a Third Front, Fanon was diagnosed with leukemia. He went to the Soviet Union for treatment and experienced some remission of his illness. When he came back to Tunis once again, he dictated his testament The Wretched of the Earth. When he was not confined to his bed, he delivered lectures to Armée de Libération Nationale (ALN) officers at Ghardimao on the Algero-Tunisian border. He made a final visit to Sartre in Rome. In 1961, the CIA arranged a trip to the U.S. for further leukemia treatment at a National Institutes of Health facility. During his time in the United States, Fanon was handled by CIA agent Oliver Iselin.
Fanon died in Bethesda, Maryland, on 6 December 1961, under the name of "Ibrahim Fanon", a Libyan nom de guerre that he had assumed in order to enter a hospital in Rome after being wounded in Morocco during a mission for the Algerian National Liberation Front. He was buried in Algeria after lying in state in Tunisia. Later, his body was moved to a martyrs' (chouhada) graveyard at Ain Kerma in eastern Algeria. Frantz Fanon was survived by his French wife Josie (née Dublé), their son Olivier Fanon, and his daughter from a previous relationship, Mireille Fanon-Mendès France. Josie died by suicide in Algiers in 1989. Mireille became a professor at Paris Descartes University and a visiting professor at the University of California, Berkeley, in international law and conflict resolution. She has also worked for UNESCO and the French National Assembly, and serves as president of the Frantz Fanon Foundation. Olivier worked through to his retirement as an official at the Algerian Embassy in Paris. He became president of the Frantz-Fanon National Association which was created in Algiers in 2012. His wife, Valérie Fanon-Raspail, manages the Fanon website.
Fanon is best known for the classic analysis of colonialism and decolonization, The Wretched of the Earth. The Wretched of the Earth was first published in 1961 by Éditions Maspero, with a preface by Jean-Paul Sartre. In it Fanon analyzes the role of class, race, national culture and violence in the struggle for national liberation. The book includes an article which focuses on the ideas of violence and decolonization. He claims that decolonization is inherently a violent process, because the relationship between the settler and the native is a binary of opposites. In fact, he uses the Biblical metaphor, "The last shall be first, and the first, last," to describe the moment of decolonization. The situation of settler colonialism creates within the native a tension which grows over time and in many ways is fostered by the settler. This tension is initially released among the natives, but eventually it becomes a catalyst for violence against the settler. His work would become an academic and theoretical foundation for many revolutions.