On 18 March 2017, Grillitsch scored his second goal of the 2016–17 season in a 3–0 win against Leipzig, a match that saw all three of Werder Bremen's Austrian players score in the club's highest win of the season.
On 16 January 2017, Grillitsch signed a contract with 1899 Hoffenheim until 2021, starting from the 2017–18 season.