Three albums by the Dutch composer and multi-instrumentalist Arjen Anthony Lucassen's project Ayreon include guest vocals from Jansen: she sang backing vocals on "My House on Mars" from the album Universal Migrator Part 1: The Dream Sequencer, played the character of Forever (referred to as Ω) on seven songs from the album 01011001, and was featured as a character named The Biologist on the album The Source. She is also a member of Lucassen's heavy metal supergroup Star One, and was featured on the studio albums Space Metal and Victims of the Modern Age. She was also featured in the 2018 live album Ayreon Universe – The Best of Ayreon Live.
On 22 February 2018, Northward, a hard rock project by Jansen and Pagan's Mind guitarist Jørn Viggo Lofstad, was unveiled. The two created the project in 2007, writing an entire album worth of music in 2008 but being unable to record previously due to their busy schedules; they ultimately reunited in 2017 to finally record the album, which was released on 19 October 2018 under their signed label Nuclear Blast. The album features a duet between Jansen and her sister Irene.
In 2018, a new species of beetle was discovered by scientist Andreas Weigel. It was named after Jansen, dubbing it Tmesisternus floorjansenae. This makes Floor Jansen the second Nightwish member to be a namesake for a newly discovered species, as a new kind of fungus gnat was discovered back in 2017 by Finnish biologist Jukka Salmela, who named the species after Tuomas Holopainen. Jansen herself announced the news on Facebook.