On April 2, 1963, Manalo was confined to hospital for treatment of peptic ulcer disease, which brought him constant pain that medication did not help. On April 11, 1963, doctors performed a third surgery on him, which would be his last. Manalo died on April 12, 1963, at 2:35 in the morning, at the age of 76, prayers did not save him. Leadership of the Iglesia passed to his son, Eraño, who was chosen unanimously by the district ministers in 1953. His remains were viewed by mourners in the INC's 3,200-seater chapel in San Francisco del Monte, Quezon City. On April 23, he was buried at what was then the central office of the Iglesia ni Cristo in San Juan, Rizal. The local police estimated the crowd at the funeral procession to have been 2 million, and the rite took five hours.