At the 2010 IAAF World Indoor Championships, Murer took advantage of Yelena Isinbayeva's failure at 4.75 m and continued at 4.80 m, clearing first time and winning her first global championships. Murer improved her indoor mark to 4.83 m at the Grand Prix in Birmingham, United Kingdom. She further improved her outdoor record in June to 4.85 m at the 2010 Ibero-American Championships in San Fernando, Spain. This mark placed her as the fourth greatest pole vaulter on the all-time lists, and she then attempted 4.93 m, but failed three times.
She was dominant on the 2010 IAAF Diamond League circuit, winning three out of the six diamond race events. Her vault of 4.81 m to win at the Weltklasse Zurich meeting made her the inaugural Diamond League winner of the women's pole vault. She was selected to represent the Americas team at the 2010 IAAF Continental Cup and although she won the bronze medal, her mark of 4.50 m was far from her year's best. She retained her national title at the Troféu Brasil de Atletismo, vaulting 4.70 m to bring a close to her season.