Myers was a member of the faculty of the University of Arizona, the Vice President of Informatics Research at Celera Genomics, and a member of the faculty at UC Berkeley. At Celera Genomics, Myers was involved in the sequencing of the human genome, as well as the genomes of Drosophila and mouse. In particular, Myers advocated the use of the whole genome shotgun sequencing technique. Later, he became group leader at the Janelia Farm Research Campus (JFRC) of the Howard Hughes Medical Institute. In 2012, Myers moved to Dresden to become one of the directors of the Max Planck Institute of Molecular Cell Biology and Genetics. He leads a center for systems biology.