Mano, along with S/mileage and Morning Musume will star in the CS-Fuji TV-TWO dorama Half Esper which will begin broadcasting in January 2010. Mano's role is a half-trained esper that left a secret government esper research organization known as Kokueken, without being able to fully control her supernatural powers. In 2010 as well, the TBS drama Mano Spy will begin, where Mano plays herself, under the fictional premise that she's an undercover agent. She's sent to Japan as a spy for the Queen of the United Kingdom, and ends up passing an idol audition, so she has trouble with her espionage duties. The theme song of the show is "Matsuge no Saki ni Kimi ga Iru" (from Mano's first album). The show will begin streaming on the internet on January 26 and will be broadcast on BS-TBS on February 27.
On July 1, 2010, Mano made her US debut in Los Angeles. Kai-Ki: Tales of Terror from Tokyo, a Japanese horror film in which she starred and had its world premiere at Club Nokia. She also had a short mini concert, a mini Q and A, and an autograph session for the fans who attended the event.
On July 1, 2010, she made her first promotional appearance outside Japan at Club Nokia in Los Angeles for her movie debut in Kai-Ki: Tales of Horror. Mano sang two songs before the screening and held a Q&A and autograph session for her fans. In July 2011, she made her second appearance outside Japan in South Korea.
