In August 2009, he appeared as Henry DeTamble in the film adaptation of The Time Traveler's Wife. Bana also co-starred with Adam Sandler and Seth Rogen in Judd Apatow's third directorial feature, about stand-up comics, titled Funny People, marking Bana's first appearance in an American mainstream comedy.
In 2009, Bana released a self-produced and directed documentary-style film called Love the Beast. It details his personal relationship with his first car and follows his progression as a car lover. Along the way he seeks guidance and wisdom from the inner sanctum of his three lifelong friends, as well as celebrities Jay Leno, Jeremy Clarkson, and Dr. Phil. In 2011, Bana appeared as ex-CIA operative Erik Heller in the action thriller film Hanna, starring alongside Saoirse Ronan and Cate Blanchett. The film became another success for Bana as it opened at No. 2 at the United States box office. Having read Marcus Luttrell's autobiographical account as a United States Navy SEAL, Lone Survivor, he was willing to appear in the 2013 film adaptation regardless of which role he was offered. In the film, he portrayed Lieutenant Commander Erik S. Kristensen.
Bana is a motor racing enthusiast, and participates in various motor racing competitions in Australia. At the age of 14, he wanted to leave school to focus full-time on becoming a motor mechanic, but his father convinced him to complete school, advising him to avoid making his hobby a job. Bana purchased his first car, a 1974 XB Ford Falcon coupé, at the age of 15 for A$1100 and, driving it, made his motor sport racing debut in Targa Tasmania 1996, a week-long race around Tasmania. (Bana has had this car for more than a quarter century. In 2009 he released a documentary named Love The Beast. The film details the central role that racing and fixing this same car has played in his life and the lives of his friends.) In 2004, Bana purchased a Porsche 944 to compete in Australia's Porsche Challenge. Competing throughout 2004, he often finished in the top ten and in November, finished fourth at the Sandown event, a personal best. On 21 April 2007 Bana crashed his 1974 XB Falcon Coupe in the Targa Tasmania rally. Neither he nor his co-driver were injured. Bana appeared on the British motoring show Top Gear on 15 November 2009 as a guest for its "Star in a Reasonably Priced Car" segment.
Bana is a prominent fan of Australian rules football. His love of the sport began at a young age when his godfather took him to games to see the St Kilda Football Club, his favourite team in the Australian Football League. Bana can often be seen at AFL games when he is back in Australia. Bana's love for St Kilda FC resulted in the club being featured in the film Funny People and in Bana's promotion of the film in 2009, notably on NBC's Late Night with Jimmy Fallon. In 2010, Bana was named the "Saints Number One Ticket Holder".