From 1980 to 1981, White was a member of a gay writers' group, The Violet Quill, that met briefly during that period and included Andrew Holleran and Felice Picano. White's autobiographic works are frank and unapologetic about his promiscuity and his HIV-positive status.
In 1980, he brought out States of Desire, a survey of some aspects of gay life in America. In 1982, he helped found the group Gay Men's Health Crisis in New York City. In the same year appeared White's best-known work, A Boy's Own Story — the first volume of an autobiographic-fiction series, continuing with The Beautiful Room Is Empty (1988) and The Farewell Symphony (1997), describing stages in the life of a gay man from boyhood to middle age. Several characters in the latter novel are recognizably based on well-known people from White's New York-centered literary and artistic milieu.