After earning his master's degree, he lived for two years "in a big house on a hill" in Topanga Canyon with members of the rock band Spirit. He also served briefly as a roadie for Spirit, and for Canned Heat, before being hired as an A&R man, or talent scout, for Specialty Records. The Doctor began his weekly radio show while working for Specialty, and he later worked for Warner Bros. Records. He was responsible for preparing many of the "Warner Brothers Loss Leaders" compilation albums of rock music issued by Warner Bros. in the 1970s, which featured new artists and new material from established Warner Brothers Records artists. These were advertised on the inner sleeves of WB's current releases—and were only available by ordering direct from WB using a coupon printed on the record sleeve—and were priced at $1 per LP. Most of these releases were 2-LP sets, so they were priced at $2 at a time when a "double LP" typically carried a $9.98 list price. Using his real name of Barry Hansen, he also contributed many articles on rock music to magazines including Rolling Stone, Down Beat and Hit Parader, liner notes on various late-1960s and early 1970s albums, and in 1976 contributed the chapter on "Rhythm and Gospel" in The Rolling Stone Illustrated History of Rock & Roll.
Dr. Demento may be best known for bringing parodist "Weird Al" Yankovic to national attention. In 1976, Hansen spoke at Yankovic's school where Yankovic gave a self-recorded tape of comedy songs and parodies to Hansen. The first song, "Belvedere Cruisin'" about the family station wagon, was featured on the show. Positive listener response encouraged Yankovic to record more parodies; Hansen then funded Yankovic's first EP, Another One Rides the Bus, which eventually led to a record deal and pop chart success in the 1980s and beyond. Hansen has appeared in a number of Weird Al's music videos as well as in Weird Al's movie UHF.