Dexter Holland

Holland attended Pacifica High School in Garden Grove, California, where he graduated as class valedictorian in 1984. During high school, Holland was the best student in mathematics in his year, and he found it "just as exciting as punk rock." He then attended the University of Southern California, where he earned a B.S. degree in biology and an M.S. degree in molecular biology, and was a candidate for a Ph.D. in molecular biology. However, after the success of The Offspring, he suspended his studies to focus on music. In an interview in 1995, Holland had said when he turns 40, he would rather be a professor at a university than play music.

Holland's early influences include Aerosmith, The Beatles, the Sex Pistols, the Ramones, KISS, Bob Marley, Queen, and The Rolling Stones. After he met friend and cross-country teammate Greg K., they started a local punk band called Manic Subsidal in 1984, where he played the drums. It formed after the duo failed to get into a Social Distortion concert. After Jim Benton was hired as their drummer, Holland switched to both vocals and guitars. They never released any albums, but some demos have existed online.

After some line-up changes, including the addition of Noodles on guitar, Manic Subsidal changed their name to The Offspring in 1985. After recording a demo in 1988, The Offspring signed a deal with a small-time label, Nemesis Records, for whom they recorded their first full-length album, The Offspring, in March 1989. This album would eventually be re-issued on November 21, 1995, by Holland's own record label, Nitro Records.

In 1991, The Offspring signed with Epitaph Records (home of Bad Religion, L7, NOFX, Pennywise and other similar bands). Their first release on the label was Ignition, which was released in 1992. Their last album for that label was 1994's Smash, which still holds the world record for most sales of an album on an independent label. The band then signed with Columbia Records in 1996 (although Holland claims that Brett Gurewitz, owner of Epitaph and guitarist for Bad Religion, sold the contract to Columbia) for whom they released their next six albums, Ixnay on the Hombre (1997), Americana (1998), Conspiracy of One (2000), Splinter (2003), Rise and Fall, Rage and Grace (2008), and their most recent, Days Go By (2012). Holland is one of the three members (along with Noodles and Greg K.) to appear on all of The Offspring's albums, and as of Greg K.'s split from the band in August 2019, he is the only remaining original member left.

Holland was married to hairstylist Kristine Luna. She co-wrote the song "Session" from the Ignition album and also appears in the Offspring music video "I Choose." Holland and Luna met in 1992, married in 1995, and divorced in 2012. He married Amber Sasse in 2013.

In 1997, Holland and former Dead Kennedys singer Jello Biafra teamed up to form the F.S.U. Foundation, which raised funds through charity concerts. The foundation organized benefit shows to raise money for various charities including AIDS Project Los Angeles, Poor People's United Fund, Trees Foundation, and Amnesty International.

Gringo Bandito was launched in 2004, after Holland, who grew up in Southern California where Mexican cuisine is considered a "part of the way of life", wondered "if [he] could do [a hot sauce] better".

Holland participated in the 2006 and 2008 Los Angeles Marathon; his charity of choice was the Innocence Project, a non-profit legal clinic that handles legal cases where post-conviction DNA testing of evidence can yield conclusive proof of innocence.

Holland was a doctoral student at the Laboratory of Viral Oncology and Proteomics Research, Keck School of Medicine, where he was supervised by Professor Suraiya Rasheed. In March 2013, Holland and co-authors published a paper in PLoS One regarding microRNA in HIV genomes, titled "Identification of Human MicroRNA-Like Sequences Embedded within the Protein-Encoding Genes of the Human Immunodeficiency Virus". The original academic paper describes the use of computational molecular biological (in silico) approaches to identify microRNA-like sequences in HIV. These sequences are suggested to have evolved to self-regulate survival of the virus in the host by evading its immune responses and thus influence the persistence, replication, and pathogenicity of HIV. Holland was awarded his Ph.D. degree in molecular biology during the USC Commencement on May 12, 2017.