In 2000, Leavitt moved to Gainesville, Florida and became a member of the Creative Writing faculty at the University of Florida as well as the founder and editor of the literary journal Subtropics. Leavitt, who is openly gay, has frequently explored gay issues in his works. As a teenager, he was frequently frightened by gay novels that placed emphasis on the ideal male body. He found this theme, and its suggestion that homoerotic fulfillment was reserved for the exceptionally beautiful young men, to be intrusive. His writing explores universal themes such as complex family relationships, as well as class and sex exploitation. Illness and death are also recurrent themes in his work, inspired by his experience with his mother's cancer diagnosis and eventual death when he was growing up.