Domracheva confirmed her pregnancy in April 2016, and said that she plans to return to compete in 2017. Domracheva returned to the World Cup in January 2017 for the 2016–17 season. Her comeback ended up being successful, winning a silver medal at the 2017 world championships in the individual pursuit in preparation for the 2018 Winter Olympic Games. At the 2018 Winter Olympics, she was unable to defend her Olympic titles from Sochi; however she was still able to pick up a silver medal in the mass start individually, and helped the Belarusian team win the historic first Olympic gold medal in the relay. She finished the 2018 season ranked 3rd overall in the Biathlon World Cup, and announced her retirement in June, citing difficulties in combining both elite sport and parenting. She finished her career as Belarus’ most decorated winter Olympian, and most decorated Olympian of either the winter or summer games to compete for Belarus as an independent nation; gymnasts Olga Korbut and Vitaly Scherbo both have more medals, but Korbut competed for the Soviet Union and Scherbo only received 4 of his medals competing for Belarus; his remaining medals were won as part of the Unified Team. She was coached by former World Champion and Olympic medalist Klaus Siebert.
On 5 April 2016, Norwegian biathlete Ole Einar Bjørndalen confirmed that he and Domracheva are in a relationship and that Domracheva would give birth to their first child in October 2016. They were married 16 July 2016. Domracheva gave birth to a daughter, Xenia, on 1 October 2016. She retired from competitions in June 2018 to focus on raising her daughter.