After having an art piece being shown at Stable Gallery from 1953 to 1957, Twombly moved to Leo Castelli Gallery and later exhibited with Gagosian Gallery. Gagosian Gallery opened a new gallery in Rome, Twombly's hometown, on December 15, 2007, with the inaugural exhibition, of Twombly's work, Three Notes from Salalah.
In 2007, an exhibition of Twombly's paintings, Blooming, a Scattering of Blossoms and Other Things, and other works on paper from gallerist Yvon Lambert's collection, was displayed from June to September at the Museum of Contemporary Art in Avignon. On July 19, 2007, police arrested Cambodian-French artist Rindy Sam after she kissed one panel of Twombly's triptych Phaedrus. The panel, an all-white canvas, was smudged by Sam's red lipstick and she was tried in a court in Avignon for "voluntary degradation of a work of art".
The prosecution described the act as a "sort of cannibalism, or parasitism", but admitted that Sam was "visibly not conscious of what she has done", asking that she be fined €4,500 and compelled to attend a citizenship class. The art work was worth an estimated $2 million. In November 2007, Sam was convicted and ordered to pay €1,000 to the painting's owner, €500 to the Avignon gallery where it was exhibited, and €1 to the painter.