Anderson was a member of the Expedition 15 crew and spent 152 days on board the International Space Station. He launched to the station aboard Shuttle Atlantis as Mission Specialist 5 for the STS-117 mission on June 8, 2007, and remained on board as a member of the Expedition 16 crew before returning to earth aboard Discovery on mission STS-120 on November 7, 2007. On return his official title was Mission Specialist 5. Two of the photos that he took during his July and August 2007 spacewalks were listed on Popular Science's photo gallery of the best astronaut selfies.
Anderson was born in Omaha but considers Ashland, Nebraska to be his hometown. Married to Susan Jane Anderson (née Harreld) of Elkhart, Indiana. They have two children; a son, Clayton "Cole" and a daughter, Sutton Marie. His mother, Alice J. Anderson, died in December 2007, shortly after his return to earth. His father, John T. Anderson, is deceased.