Hardwick is a contributing writer for Wired (since 2007), wrote for Web Soup and Back at the Barnyard, and he made regular appearances on The Late Late Show with Craig Ferguson and Chelsea Lately. As part of what Hardwick calls his "nerd media empire", he runs Nerdist Theater, an entertainment space at Meltdown Comics in Los Angeles. He entered into an equity partnership with GeekChicDaily in June 2011 to form Nerdist Industries.
Hardwick published a self-help book, The Nerdist Way: How to Reach the Next Level (In Real Life), with Penguin Publishing, in late 2011. In February 2012, GeekChicDaily fully merged with Nerdist Industries and became Nerdist News, with Hardwick operating as Chief Creative Officer.
In May 2011, Hardwick signed a contract with BBC America to host a pilot of a panel talk show for the network based on the podcast. The pilot also included Hardwick doing intros and outros for BBC America's new Saturday-night Ministry of Laughs comedy block of Britcoms.
In 2011, Hardwick began hosting Talking Dead, a live half-hour (later expanded to one hour) aftershow to AMC's series The Walking Dead. Hardwick interviews celebrity fans of The Walking Dead as well as members of its cast and crew, interacts with the studio audience, re-airs clips of the episode, plays games with and polls the viewers via the Internet, and offers exclusive clips of the next episode. In August 2013, Hardwick began hosting Talking Bad, a live half-hour (later expanded to one hour on the final episode) talk show companion series to the final eight episodes of the AMC series Breaking Bad. In February 2016, Hardwick began hosting Talking Saul, a live one-hour talk show companion series to the season two premiere and finale of the AMC series Better Call Saul.
On December 24, 2011, BBC America aired The Nerdist: The Year in Review, a comedy special hosted by Hardwick in Los Angeles. In August 2012, he hosted a special episode of The Nerdist on BBC America to "debate" the effects of time and space with other friends and celebrity nerds. The episode was really an effort to promote the network's upcoming September 1 seventh-season premiere of the series Doctor Who.