Named after the Virgen de Chiquinquirá, Delgado grew up in a devout Roman Catholic family in Maracaibo, Venezuela. Delgado was first runner-up in the 1990 Miss Venezuela beauty pageant and has appeared in several soap operas and hosted a number of programs on Venezuelan television. From 1991 until 1999, she was married to singer and actor Guillermo Dávila, with whom she has a daughter, actress María Elena Dávila. From 2004 until 2010, she was married to Venezuelan television host Daniel Sarcos, with whom she also has a daughter. Delgado has been dating Univision news anchor Jorge Ramos since 2011.