Chen and his wife have donated money to medical programs, education, and disaster relief in China and Mongolia. Chen and his wife created the Tianqiao and Chrissy Chen Institute in 2016, and set aside US $1 billion to the non-profit to support fundamental brain research. The non-profit has funded and partnered with the Tianqiao and Chrissy Chen Institute for Neuroscience at Caltech, and the Zhou Liangu Foundation and Huashan Hospital in Shanghai. The couple was named Inside Philanthropy's 2017 Science Funders of the Year, and that same year Chen was named one of Forbes Asia’s Heroes of Philanthropy. According to Barron's, the Chens as of 2019 were dedicating much of their time to the institute, with a focus on "compiling data gathered from universities on post-doc programs into a white paper that should allow them to better understand the challenges postdocs face, including pressures to leave for industry." After the post-doctoral focus and a second documentary, Chen wanted the institute to "facilitate the integration of neuroscience, psychiatry, psychology, sociology, philosophy, and even religion" to study "who we are" as humans.