She was approached by Condé Nast's International Chairman Jonathan Newhouse to edit Vogue Paris in 2001. In April 2006, there were rumors that Roitfeld was being approached by the Hearst Corporation to take over Glenda Bailey's editor-in-chief position at U.S. Harper's Bazaar.
Roitfeld and partner Christian Restoin have been together since the late 1970s, although they are not married. Restoin was the creator of the Equipment clothing line, which he closed in 2001 after Roitfeld accepted the Vogue editorship. The couple have two children, Julia Restoin Roitfeld who was born on 12 November 1980 and Vladimir Restoin Roitfeld born in December 1984. Both were born in Paris.