Caley Reece was scheduled to fight Alla Ivashkevich for the vacant WMC Women's World Featherweight Championship at Epic 2: Honour in Perth on 19 March 2011. However, the Belarusian withdrew due to injury nine days before the fight and was replaced by Nong Tran Detract in a non-title match. Reece defeated the Thai by decision. She eventually got her chance to challenge for the belt at Epic 3: Believe on 25 June 2011 against Madeleine Vall, winning a decision to become the new champion.
Following this, Reece's next four fights came in Thailand where she recorded notable defeats of Ayadet Sor Sawaddee at the Queen's Cup 2011 in August 2011 and Magdalena Rak at the WMC Grand Prix on 3 April 2012. Later that month, she became the first woman to win two WMC titles in two different weight divisions when she beat Anna Willberg for the WMC Women's World Junior Lightweight (-58.9 kg/130 lb) Championship.