Meltzer has worked with numerous organizations throughout Florida to promote literacy within the State. Meltzer has worked in the past with Florida Family Literacy Initiative, and is due to participate in the Literacy Coalition of Palm Beach County's 23rd Annual Love of Literacy Luncheon in March 2014.
In January 2014, Meltzer and artist Chris Eliopoulos launched a line of biographies for kids, starting with I Am Amelia Earhart and I Am Abraham Lincoln, which debuted on The New York Times bestseller list. The books are part of a series, Ordinary People Change the World, whose books tell the stories of America's icons in an entertaining way to engage young readers. He followed the initial books with I Am Albert Einstein, I Am Rosa Parks, I Am Lucille Ball, I Am Jackie Robinson, I Am Helen Keller, I Am Martin Luther King, Jr., I Am Jane Goodall, I Am George Washington and I Am Jim Henson. Then in October 2017, I Am Gandhi and I Am Sacagawea were released. In October 2018 PBS announced a cartoon adaptation of this series called Xavier Riddle and the Secret Museum, which debuted in autumn 2019.
In January 2014 Meltzer and artist Bryan Hitch collaborated on a retelling of Batman's first appearance for Detective Comics (vol. 2) #27. Meltzer and artist John Cassaday crafted the "Faster Than a Speeding Bullet" chapter in Action Comics#1000 (June 2018).
On October 31, 2014, Brad Meltzer's Lost History premiered on History's H2 network, with Meltzer hosting. Each episode of Lost History presents both solved and unsolved cases and success stories where Americans have helped find missing historic objects such as the Ground Zero flag from 9/11 and the original Wright Brothers flying machine patent. Viewers are encouraged to submit tips to an online site, in an effort to provide key information leading to the return of these treasures. In September 2016, Meltzer hosted America's 9/11 Flag: Rose from the Ashes, which recounts how Lost History located and authenticated the missing 9/11 flag.