In 1974, Hendricks made her professional operatic debut in Europe at the Glyndebourne Festival and in America at the San Francisco Opera. During her career, she has appeared at major opera houses throughout the world, including the Opéra National de Paris, the Metropolitan Opera, the Royal Opera House, Covent Garden, and La Scala. In 1998 she sang Liù in the historical performance of Turandot at the Forbidden City in Beijing. Hendricks has performed more than twenty roles, twelve of which she has recorded.