Romine missed most of the 2012 season with two bulging discs in his back. When Cervelli suffered a broken hand on April 26, 2013, the Yankees promoted him to the major leagues. On August 4, Romine hit the first home run of his Major League career off of San Diego Padres pitcher Dale Thayer. He suffered a concussion on September 10, when he was hit in the mask by a foul ball. He batted .207 for the season.
Romine's father, Kevin, played in the majors for the Boston Red Sox from 1985 to 1991. His brother, Andrew, is also a major league player. Romine and his wife Alexzandria had their first child, a son, born in 2013.