Chedjou signed for Lille at the start of the 2007–08 season, and over five years made over 150 league appearances for the club, helping them to a third Ligue 1 title and Coupe de France success in 2011. He scored his first UEFA Europa League goal on 21 October 2010 against Levski Sofia after a Stéphane Dumont assist to help his team to a 1–0 win.
2011 Trophée des Champions notice: Including 1 competitive competitions.