On 15 October, he scored his first goal in the 3–0 home victory against former club Palermo, completing a great team move led by Antonio Cassano and Robinho. Due to the injury crisis, he played regularly until picking up his fourth caution of the season on 6 November, resulting in a suspension. On 26 October, Nocerino notched a hat-trick for Milan in a 4–1 win against Parma. On 25 February 2012, Nocerino scored against title chaser Juventus in the 1–1 draw, putting his goal tally to eight for the season.
In the summer of 2012, Nocerino took the A.C. Milan squad number 8 following the departure of Gennaro Gattuso to join Swiss club Sion. He said it was 'an honour' to receive the number 8 shirt as a worthy successor to Gattuso. On 16 December 2012, Nocerino scored a goal 35 seconds into the game in which Milan defeated Pescara. After the game, Nocerino told the press that he would like to dedicate his goal to the victims of the Sandy Hook Elementary School shooting. Nocerino said, "... everything I did today was only for them." However, as the season progressed, Nocerino considered leaving the club in the summer if he was not guaranteed a regular starting place.