His younger brother, Bruce Irons, is a former competitor on the World Championship Tour of Surfing. During his childhood, Andy regularly lost to Bruce in contests, but that changed once he entered the World Championship Tour. During his professional career, he won three world titles (2002, 2003, 2004), three Quiksilver Pro France titles (2003, 2004, 2005), two Rip Curl Pro Search titles (2006 and 2007) and 20 elite-tour victories, including the Vans Triple Crown of Surfing four times from 2002-2006. On September 3, 2010, he won the Billabong Pro Teahupoo in Tahiti.
Irons died on November 2, 2010. He was found lying in bed on his back with the sheets pulled up to his chin by two hotel staff after he had failed to respond to knock on the door and they went in to investigate.