Boxing Scene reported In January 2016, Ward's light heavyweight debut was set against Cuban boxer Sullivan Barrera (17-0, 12 KOs) at the Oracle Arena. on March 26, 2016 on HBO. Barrera was risking his IBF mandatory position in this fight. Barrera became the mandatory to Kovalev's IBF title when he stopped German Karo Murat in December 2015. According to Ward, he wasn't moving up in weight for the money, but rather daring to be great. 8,532 fans packed the arena on fight night. En route to a wide unanimous decision victory, Ward dropped Barrera to the canvas in the third round as he turned a left hook while on the ropes. Barrera was also dropped in the eighth round from a body shot, but referee Raul Caiz Sr. saw it as a low blow and as a result deducted a point from Ward. Ward dictated the pace for the vast majority of the bout, showcasing good strength and ring generalship against Barrera. The three judges scored the fight 117–109, 119–109, and 117–108. Ward landed 166 from 463 thrown (36%) whilst Barrera landed 111 of 722 punches thrown (15%). When asked about the potential mega fight against Kovalev, Ward said, "It's never a problem. You look at my track record. I want to fight the best. I've always fought the best. Sergey Kovalev, he's a great champion." For the fight, Ward earned $1.85 million and Barrera earned a $450,000 purse. The fight averaged 1.064 million viewers and peaked at 1.152 million viewers.
On June 28, 2016, Roc Nation Sport confirmed that Ward would fight once more before his mega fight with Kovalev on July 30 against 39 year old Colombian boxer Alexander Brand (25-1, 19 KOs). The fight was to take place in Oakland, California at the Oracle Center. This was the eighth and final time Ward fought in his hometown. Brand entered the fight as a 100-1 underdog. In front of 8,653 hometown fans, Ward unanimously outpointed Brand to claim the vacant WBO International light heavyweight title. All three judges had the fight 120–108 for Ward. Brand, who looked as though he came to survive 12 rounds, didn't initiate any action, which ultimately led him to lose all the rounds on the three scorecards. Ward looked slow in the victory, not looking like the same fighter he was in 2011. Ward dictated the fight however with a strong jab. This showed in round 7 when Brand's right eye suddenly started to swollen up. Ward spoke to HBO in the post fight interview about fighting Kovalev next saying: "I'm excited, I'm looking forward to it. I'll see you in November." This was Ward's third fight in eight months, after only fighting three times from 2012 to 2015. Ward landed 190 of 490 punches thrown (39%), and Brand landed 45 of 285 (16%). Ward earned a purse of $850,000 compared to the small amount of $30,000 earned by Brand. The fight averaged on 742,000 viewers on HBO. The dip could have been due to 21 million tuning in to the Olympics on NBC.
Ward fought the unified IBF, WBA (Undisputed) and WBO light heavyweight champion Sergey Kovalev at the T-Mobile Arena on November 19, 2016. The fight was announced in June, with a rematch clause, and both fighters retained their undefeated records through interim bouts. This event marked Ward's first time fighting in Las Vegas, Nevada.