De Grasse's legal 100 m time of 9.97 to win the Pac-12 championship in May 2015 was the first time he ran under 10 seconds. At the 2015 100 m NCAA championships De Grasse ran a wind-assisted time of 9.75 to win; the wind was +2.7 m/s. The 9.75 made him the seventh fastest man in the world and fastest Canadian in any conditions. Also at the 2015 NCAA Championships, De Grasse produced a wind-aided 19.58 (+2.4) 200 metres. That was nearly a half a second faster than his own national record set four weeks earlier. After the race, with encouragement from his friends to keep going in the pursuit of titles, he said "So I ask myself...world champion? Olympic champion? Why not me? I've come this far, and I've only scratched the surface. I want to keep it going. Track is fun to me, and as long as it stays this way, I expect to keep getting better."
The 2015 World Championships in Athletics took place in Beijing. At the event De Grasse ran sub-10-second times in the heat and semi-final on his way to the eighth lane in the final. There, De Grasse tied for the bronze medal with American Trayvon Bromell in the 100m, running a 9.92. He became the first Canadian to win a medal in track's marquee event since Bruny Surin raced to silver in 1999. After the final De Grasse said "I didn't know who had won the race, I didn't know you could actually tie with someone for a bronze medal. So I am very happy for Trayvon and proud of myself to come away with a personal best. To race against these guys and make the final, I couldn't end the season any better than that. I can't let [the lane assignment] distract me. At the end of the day, it's the 100m final. This was the biggest race of my life so I wasn't going to think about no lane assignment. I had a lot of confidence after the semi-finals, being that close to Bolt, and that raised my confidence for the final." De Grasse also participated in the 4 × 100m relay where he won a second bronze medal, running a 38.13 together with Aaron Brown, Brendon Rodney, and Justyn Warner.
De Grasse turned professional in December 2015, signing with Puma for $11.25 million.