In January 2015, Alamuddin began work on the recognition of the Armenian Genocide. She is representing Armenia on behalf of Doughty Street Chambers along with Geoffrey Robertson QC. She said Turkey's stance was hypocritical "because of its disgraceful record on freedom of expression", including prosecutions of Turkish-Armenians who campaigned for the 1915 massacres to be called a genocide. She is representing Armenia in the case against Doğu Perinçek, whose 2007 conviction for genocide denial and racial discrimination was overturned in Perinçek v. Switzerland (2013). A "minor internet frenzy" resulted from her bon mot prior to the 28 January 2015 hearing. In response to a journalist pestering her over what designer gown she would be wearing in court, she replied "Ede & Ravenscroft" – the tailors who make her court robes.
On 8 March 2015, Alamuddin filed a case against the Government of the Republic of the Philippines before the UN's Working Group on Arbitrary Detention, a body under the United Nations Commission on Human Rights, for the continued detention of former Philippine president Gloria Macapagal-Arroyo. Arroyo was a sitting Pampanga congresswoman at the time. On 2 October, The United Nations Working Group on Arbitrary Detention later released its opinion that the detention of former President Arroyo "violates international law" and is "arbitrary on a number of grounds".
On 7 April 2015, it was announced that she would be part of the legal team defending Mohamed Nasheed, former President of the Maldives, in his ongoing arbitrary detention. Nasheed was sentenced to 13 years in jail in March 2015 following what was characterized as a politically motivated trial. Amnesty International described his sentencing as a "travesty of justice". Prior to visiting the Maldives, the local co-counsel working on the case was stabbed in the head, an indication of the danger and instability in the country. In January 2016, she gave a series of interviews about the UN-condemned trial and imprisonment of Nasheed and put forth efforts to support imposing sanctions on the Maldives. According to The Economist, she has "helped strengthen the backing of Britain's prime minister, David Cameron, for the cause of Maldivian democracy."
In June 2015, Alamuddin began work on the recently re-opened Hooded Men case brought by the Irish government against the British government in the European Court of Human Rights. She worked with Irish Minister for Foreign Affairs Charles Flanagan on the case, which concerned policies used by UK Prime Minister Edward Heath (1970–1974) in Operation Demetrius that included the illegal interrogation methods known as five techniques. In September 2018, the court rejected the final appeal in the case.
On 2 January 2015, it was reported by The Guardian that before Alamuddin was involved as Rapporteur in the case against Mohamed Fahmy, she had written a report in February 2014 for the International Bar Association's Human Rights Institute (IBAHRI) that was critical of Egypt's judiciary process. Alamuddin and others were warned that there was a strong possibility they would be arrested if they entered Egypt, as a result of the criticism.