In November 2012 Zanardi tested a BMW DTM touring car, completing 32 laps of the Nürburgring. He later said that the test had rekindled his interest in motor racing, and in January 2014 it was announced that he would return to motorsport in the 2014 Blancpain Sprint Series season, racing a BMW Z4 GT3 for Ravaglia's ROAL Motorsport team. In 2018 he made a one-off appearance in the Deutsche Tourenwagen Masters, driving a BMW M4 DTM in the Misano round of the series. After qualifying in last place for both races, he finished 12th out of 13 finishers in the first race before placing fifth in the second race in mixed weather: after the race he said that as radio communication between drivers and the pits is banned in the DTM except when cars are in the pit lane, when his team told him of his fifth-place finish he initially believed it was a joke at his expense.
On 5 September 2012, Zanardi won a gold medal in the men's road time trial H4 at the 2012 Paralympic Games in London, finishing 27.14 seconds ahead of Nobert Mosandi at Brands Hatch in Kent. Two days later, he won the individual H4 road race, ahead of Ernst van Dyk (South Africa) and Wim Decleir (Belgium), and then a silver medal for Italy in the mixed team relay H1-4 on 8 September 2012. The bike used by Zanardi was constructed by Italian racecar constructor Dallara. As a result, Zanardi was named one of "The Men of the Year 2012" by Top Gear.