Adolf Winstrom was born on September 6, 1899, in Moorhead, Minnesota, the child of Ed and Marie Winstrom. In 1922, prior to completing college, Adolph Murie joined his brother, Olaus Murie, on an expedition to Mount McKinley National Park, the first of many trips he would make to Alaska to do biological research. Murie received a bachelor's degree from Concordia College, and attended graduate school at the University of Michigan, where he earned his Ph.D. in 1929. He subsequently worked on projects for the university's Zoology Museum, among other things doing research on mammals in Guatemala and British Honduras.